منابع مشابه
Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo.
Mastermind (Mam) is one of the elements of Notch signaling, a system that plays a pivotal role in metazoan development. Mam proteins form transcriptionally activating complexes with the intracellular domains of Notch, which are generated in response to the ligand-receptor interaction, and CSL DNA-binding proteins. In mammals, three structurally divergent Mam isoforms (MamL1, MamL2 and MamL3) ha...
متن کاملMastermind-Like 1 Is Ubiquitinated: Functional Consequences for Notch Signaling
Early studies demonstrated the involvement of ubiquitination of the Notch intracellular domain for rapid turnover of the transcriptional complex at Notch target genes. It was shown that this ubiquitination was promoted by the co-activator Mastermind like 1 (MAML1). MAML1 also contains numerous lysine residues that may also be ubiquitinated and necessary for protein regulation. In this study, we...
متن کاملMastermind Revisited
For integers n and k, we define r(n, k) as the average number of guesses needed to solve the game of Mastermind for n positions and k colours; and define f(n, k) as the maximum number of guesses needed. In this paper we add more small values of the two parameters, and provide exact value for the case of n = 2. Finally we comment on the asymptotics.
متن کاملStatic Mastermind
Static mastermind is like normal mastermind, except that the codebreaker must supply at one go a list of questions (candidate codes), the answers to which must uniquely determine the secret code. We confirm the minimum size list for some small values. Then we solve the game for up to 4 positions. In particular we show that for k sufficiently large the minimium size of a list for 4 positions and...
متن کاملTranslocation t(2;11) in CLL cells results in CXCR4/MAML2 fusion oncogene.
Recent investigations of chromosomal aberrations in chronic lymphocytic leukemia (CLL) led to a better understanding of the molecular causes of CLL. Here we report a rearrangement between MAML2 (mastermind-like protein 2) and CXCR4 (specific receptor for CXC chemokine stromal cell-derived factor-1) in CLL cells of a patient with a t(2;11)(q22.1;q21) chromosomal translocation. The rearrangement ...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/37983